The South African Centre for Epidemiological Modelling and Analysis (SACEMA) is a national research centre established under the Centre of Excellence programme of the Department of Science and Technology and the National Research Foundation.

The Centre focuses on research in quantitative modelling of the spatial and temporal patterns of disease. The immediate aim of the research is to understand and predict the development of various diseases, and thereby to provide advice on how best to combat them. Initial research will focus on issues pertaining to HIV, TB and malaria, although not to the exclusion of other epidemiological problems.

The Centre is hosted by the University of Stellenbosch, and has its premises in an old wine cellar on the grounds of the Mostertsdrift Estate. Initially a 'hub and spoke' model will be followed, where a critical mass of staff will be located at these offices, with various branch sites situated elsewhere in South Africa.